SG_WP_Breast&Ovarian Cancers_FINAL8_PRINT.indd

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چکیده

The National Cancer Institute estimates that 12% of all women (about 1 in 8) will be diagnosed with breast cancer and 3% will be diagnosed with ovarian cancer throughout their lifetime.1,2 5-10% of all breast and ovarian cancers diagnosed are hereditary. Risk factors for hereditary breast and ovarian cancers include a family history with highly penetrant mutations in genes such as BRCA1 and BRCA2, moderately penetrant mutations in other genes (such as ATM, BRIP1, CHEK2 and PALB2 among others), as well as more common genomic variants, including single nucleotide polymorphisms, associated with modest effect sizes.3

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تاریخ انتشار 2017